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Regain begins within 2 to 3 weeks of last dose Appetite returns to pre-treatment levels or higher (rebound hyperphagia) Weight regain of 1 to 2 pounds per week for the first 8 to 12 weeks Patients report feeling "more hungry than before I started" Typically occurs in patients who made minimal dietary or behavioral changes during treatment Regain trajectory matches or exceeds the STEP 1 extension trial data (two-thirds of weight back within one year) Pattern 2: Partial regain with stabilization (approximately 45% of discontinuations)
However, headaches typically rank lower on the list of side effects compared to digestive issues, such as nausea, vomiting, or diarrhoea
Despite their potential, these medications remain underutilized among older adults
Amy BairWhite Sands Medical Group Dr
EMT is a biological process whereby epithelial cells lose their characteristic markers and acquire mesenchymal features, enabling enhanced migratory capacity
